The phase behavior of poloxamer 188 (P188) in aqueous solutions, characterized by
differential scanning calorimetry (DSC) and synchrotron X-ray diffractometry, revealed solute …

Objective The purpose of this paper is to re-visit the design of three steps in the freeze-
drying process, namely freezing, primary drying, and secondary drying steps. Specifically …

Poloxamer 188 (P188) was hypothesized to be a dual functional excipient,(i) a stabilizer in
frozen solution to prevent ice-surface-induced protein destabilization and (ii) a bulking agent …

Purpose The stability of protein drug products frozen during fill finish operations is greatly
affected by the freezing rate applied. Non-optimal freezing rates may lead to the …

Protein structural changes during freezing and subsequent thawing are of great importance
to a variety of biopharmaceutical applications. In this work, we studied the influence of non …

The purpose of this study was to investigate the mechanical stresses and strains acting on
pharmaceutical glass tubing vials during freezing and thawing of model pharmaceutical …

Hidakakombu (Saccharina angustata) is an edible brown alga produced in the Hidaka
region of Hokkaido. It is graded at the time of processing, and low‐grade products have a …

Whereas the different chapters of the book offer insights related to the use of surfactants—
their manufacturing, functionality as excipients, degradation, control, and regulatory aspects …