Scrub typhus and the rickettsial diseases represent some of the oldest recognized vector-
transmitted diseases, fraught with a rich historical aspect, particularly as applied to …

Orientia tsutsugamushi (OT), the causative agent of the vector-borne Scrub typhus zoonotic
disease in humans, is a unique microorganism that exists in the Asia-Pacific region since a …

Background Scrub typhus is a vector-borne febrile illness caused by Orientia tsutsugamushi
transmitted by the bite of Trombiculid mites. O. tsutsugamushi has a high genetic diversity …

Scrub typhus, a mite-borne infectious disease, is caused by Orientia tsutsugamushi. Despite
many attempts to develop a protective strategy, an effective preventive vaccine has not been …

How intracellular bacteria subvert the major histocompatibility complex (MHC) class I
pathway is poorly understood. Here, we show that the obligate intracellular bacterium …

Obligate intracellular bacteria have remained those for which effective vaccines are
unavailable, mostly because protection does not solely rely on an antibody response …

Orientia tsutsugamushi is the etiologic agent of scrub typhus, the deadliest of all diseases
caused by obligate intracellular bacteria. Nucleomodulins, bacterial effectors that …

Over the last decades, rickettsioses are emerging worldwide. These diseases are caused by
intracellular bacteria. Although rickettsioses can be treated with antibiotics, a vaccine …

Infection with Orientia tsutsugamushi, an obligate intracellular bacterium, can cause mild or
severe scrub typhus. Some patients develop acute lung injury, multi-organ failure, and fatal …

Rickettsioses are febrile, potentially lethal infectious diseases that are a serious health
threat, especially in poor income countries. The causative agents are small obligate …