Astrocyte-immune cell interactions in physiology and pathology
Astrocytes play both physiological and pathological roles in maintaining central nervous
system (CNS) function. Here, we review the varied functions of astrocytes and how these …
system (CNS) function. Here, we review the varied functions of astrocytes and how these …
The role of astrocytes in oxidative stress of central nervous system: A mixed blessing
Y Chen, C Qin, J Huang, X Tang, C Liu… - Cell …, 2020 - Wiley Online Library
Central nervous system (CNS) maintains a high level of metabolism, which leads to the
generation of large amounts of free radicals, and it is also one of the most vulnerable organs …
generation of large amounts of free radicals, and it is also one of the most vulnerable organs …
Interaction of mitochondrial calcium and ROS in neurodegeneration
AY Baev, AY Vinokurov, IN Novikova, VV Dremin… - Cells, 2022 - mdpi.com
Neurodegenerative disorders are currently incurable devastating diseases which are
characterized by the slow and progressive loss of neurons in specific brain regions …
characterized by the slow and progressive loss of neurons in specific brain regions …
Non-neuronal cells in amyotrophic lateral sclerosis—from pathogenesis to biomarkers
The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …
Elusive roles for reactive astrocytes in neurodegenerative diseases
L Ben Haim, MA Carrillo-de Sauvage… - Frontiers in cellular …, 2015 - frontiersin.org
Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory
response. They become reactive in response to virtually all pathological situations in the …
response. They become reactive in response to virtually all pathological situations in the …
FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms
K Stoklund Dittlau, L Terrie, P Baatsen… - Molecular …, 2023 - Springer
Background Astrocytes play a crucial, yet not fully elucidated role in the selective motor
neuron pathology in amyotrophic lateral sclerosis (ALS). Among other responsibilities …
neuron pathology in amyotrophic lateral sclerosis (ALS). Among other responsibilities …
Motor neuron susceptibility in ALS/FTD
AMG Ragagnin, S Shadfar, M Vidal… - Frontiers in …, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …
[HTML][HTML] The multi-dimensional roles of astrocytes in ALS
K Yamanaka, O Komine - Neuroscience research, 2018 - Elsevier
Despite significant progress in understanding the molecular and genetic aspects of
amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by the …
amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by the …
Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity
A Birger, I Ben-Dor, M Ottolenghi, T Turetsky, Y Gil… - …, 2019 - thelancet.com
Background Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative
disease that affects motor neurons (MNs). It was shown that human astrocytes with …
disease that affects motor neurons (MNs). It was shown that human astrocytes with …
[HTML][HTML] Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons
Non-cell-autonomous mechanisms contribute to neurodegenerative diseases such as
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), in which astrocytes …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), in which astrocytes …