Astrocyte-immune cell interactions in physiology and pathology

RT Han, RD Kim, AV Molofsky, SA Liddelow - Immunity, 2021 - cell.com
Astrocytes play both physiological and pathological roles in maintaining central nervous
system (CNS) function. Here, we review the varied functions of astrocytes and how these …

The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

Y Chen, C Qin, J Huang, X Tang, C Liu… - Cell …, 2020 - Wiley Online Library
Central nervous system (CNS) maintains a high level of metabolism, which leads to the
generation of large amounts of free radicals, and it is also one of the most vulnerable organs …

Interaction of mitochondrial calcium and ROS in neurodegeneration

AY Baev, AY Vinokurov, IN Novikova, VV Dremin… - Cells, 2022 - mdpi.com
Neurodegenerative disorders are currently incurable devastating diseases which are
characterized by the slow and progressive loss of neurons in specific brain regions …

Non-neuronal cells in amyotrophic lateral sclerosis—from pathogenesis to biomarkers

BF Vahsen, E Gray, AG Thompson, O Ansorge… - Nature Reviews …, 2021 - nature.com
The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Elusive roles for reactive astrocytes in neurodegenerative diseases

L Ben Haim, MA Carrillo-de Sauvage… - Frontiers in cellular …, 2015 - frontiersin.org
Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory
response. They become reactive in response to virtually all pathological situations in the …

FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms

K Stoklund Dittlau, L Terrie, P Baatsen… - Molecular …, 2023 - Springer
Background Astrocytes play a crucial, yet not fully elucidated role in the selective motor
neuron pathology in amyotrophic lateral sclerosis (ALS). Among other responsibilities …

Motor neuron susceptibility in ALS/FTD

AMG Ragagnin, S Shadfar, M Vidal… - Frontiers in …, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

[HTML][HTML] The multi-dimensional roles of astrocytes in ALS

K Yamanaka, O Komine - Neuroscience research, 2018 - Elsevier
Despite significant progress in understanding the molecular and genetic aspects of
amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by the …

Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity

A Birger, I Ben-Dor, M Ottolenghi, T Turetsky, Y Gil… - …, 2019 - thelancet.com
Background Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative
disease that affects motor neurons (MNs). It was shown that human astrocytes with …

[HTML][HTML] Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons

C Arredondo, C Cefaliello, A Dyrda, N Jury, P Martinez… - Neuron, 2022 - cell.com
Non-cell-autonomous mechanisms contribute to neurodegenerative diseases such as
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), in which astrocytes …