The blood–brain barrier is a dynamic and highly organized structure that strictly regulates
the molecules allowed to cross the brain vasculature into the central nervous system. The …

Glioblastoma (GB) is the most common primary malignant brain tumor, and despite the
availability of chemotherapy and radiotherapy to combat the disease, overall survival …

In silico models and computer simulation are invaluable tools to better understand complex
biological processes such as cancer evolution. However, the complexity of the biological …

Purpose: Glioblastoma multiform (GBM) is the most aggressive glial neoplasm. Researchers
have exploited the fact that GBMs are highly vascularized tumors. Anti-angiogenic strategies …

In this article, we propose a proof of concept for the automatic planning of personalized
radiotherapy for brain tumors. A computational model of glioblastoma growth is combined …

MicroRNAs (miRNAs) are small non-coding RNAs frequently dysregulated in human
malignancies. In this study, we found that miR-181c was down-regulated both in …

Background Glioblastoma (GBM) is a highly virulent tumor of the central nervous system,
with a median survival< 15 months. Clearly, an improvement in treatment outcomes is …

Brain metastases (BMs) are the most common intracranial tumor type and a significant
health concern, affecting approximately 10% to 30% of all oncological patients. Although …

Purpose Glioblastomas (GB) and solitary brain metastases (BM) are the most common brain
tumors in adults. GB and BM may appear similar in conventional magnetic resonance …

Background In this exploratory analysis of AVAglio, a randomized phase III clinical study that
investigated the addition of bevacizumab (Bev) to radiotherapy/temozolomide in newly …