ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as
discrete epigenetic changes, that can dictate both ongoing and future inflammatory …

This review summarizes the current knowledge on essential vitamins B1, B2, B3, and B5.
These B-complex vitamins must be taken from diet, with the exception of vitamin B3, that can …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

Colchicine is an ancient herbal drug derived from Colchicum autumnale. It was first used to
treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti …

Prevention of atherosclerosis is important because it is a risk factor for cardiovascular
diseases globally. One of the causes of atherosclerosis is accumulation of cholesterol and …

Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid
metabolism and a maladaptive immune response driven by the accumulation of cholesterol …

Atherosclerosis can be regarded as a chronic inflammatory state, in which macrophages
play different and important roles. Phagocytic proinflammatory cells populate growing …

Nephrotic syndrome is a highly prevalent disease that is associated with high morbidity
despite notable advances in its treatment. Many of the complications of nephrotic syndrome …

Most types of cells in the body do not express the capability of catabolizing cholesterol, so
cholesterol efflux is essential for homeostasis. For instance, macrophages possess four …