The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a
critical, evolutionarily conserved process during development and organogenesis. Analyses …

More is becoming known about so-called noncanonical Wnt pathways that signal
independently of β-catenin. Here we review recent developments in both the functions and …

It is fundamentally important that signaling gradients provide positional information to govern
morphogenesis of multicellular organisms. Morphogen gradients can generate different cell …

Morphogenesis depends on the precise control of basic cellular processes such as cell
proliferation and differentiation. Wnt5a may regulate these processes since it is expressed in …

Waardenburg-Shah syndrome combines the reduced enteric nervous system characteristic
of Hirschsprung's disease with reduced pigment cell number, although the cell biological …

Wnts make up a large family of extracellular signaling molecules that play crucial roles in
development and disease. A subset of noncanonical Wnts signal independently of the …

To rapidly identify genes required for early vertebrate development, we are carrying out a
large-scale, insertional mutagenesis screen in zebrafish, using mouse retroviral vectors as …

Planar cell polarization entails establishment of cellular asymmetries within the tissue plane.
An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra-and …

The basic vertebrate body plan of the zebrafish embryo is established in the first 10 hours of
development. This period is characterized by the formation of the anterior-posterior and …

Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of
adult cells after severe injury or amputation. Certain lower vertebrates such as urodele …