Radiotherapy (RT) has been developed with remarkable technological advances in recent
years. The accuracy of RT is dramatically improved and accordingly high dose radiation of …

Altered by ionising radiation, the vascular network is considered as a prime target to limit
normal tissue damage and improve tumour control in radiotherapy (RT). Irradiation damages …

Purpose To investigate whether the vascular collapse in tumors by conventional dose rate
(CONV) irradiation (IR) would also occur by the ultra-high dose rate FLASH IR. Methods and …

Simple Summary Stereotactic ablative radiotherapy (SABR), which irradiates tumors with
high-dose radiation per fraction, promotes anti-tumor immunity by stimulating various …

Hypoxia results from an imbalance between oxygen supply and consumption. It is a
common phenomenon in solid malignant tumors such as head and neck cancer. As hypoxic …

Pronounced resistance of lung cancer cells to radiotherapy and chemotherapy is a major
barrier to successful treatment. Herein, both tumor hypoxia and the upregulation of the …

Radiotherapy (RT) is part of standard cancer treatment. Innovations in treatment planning
and increased precision in dose delivery have significantly improved the therapeutic gain of …

Tumor hypoxia, a common feature occurring in nearly all human solid tumors is a major
contributing factor for failures of anticancer therapies. Because ionizing radiation depends …

Recent advancement in the radiotherapy technology has allowed conformal delivery of high
doses of ionizing radiation precisely to the tumors while sparing large volume of the normal …

The effect of radiation therapy on tumor vasculature has long been a subject of debate.
Increased oxygenation and perfusion have been documented during radiation therapy …