CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
Recommendations for analytical antiretroviral treatment interruptions in HIV research trials—report of a consensus meeting
B Julg, L Dee, J Ananworanich, DH Barouch, K Bar… - The lancet HIV, 2019 - thelancet.com
Analytical antiretroviral treatment interruption (ATI) is an important feature of HIV research,
seeking to achieve sustained viral suppression in the absence of antiretroviral therapy (ART) …
seeking to achieve sustained viral suppression in the absence of antiretroviral therapy (ART) …
Combination anti-HIV antibodies provide sustained virological suppression
MC Sneller, J Blazkova, JS Justement, V Shi… - Nature, 2022 - nature.com
Antiretroviral therapy is highly effective in suppressing human immunodeficiency virus (HIV).
However, eradication of the virus in individuals with HIV has not been possible to date …
However, eradication of the virus in individuals with HIV has not been possible to date …
HIV rebound is predominantly fueled by genetically identical viral expansions from diverse reservoirs
Viral rebound upon stopping combined antiretroviral therapy poses a major barrier toward
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …
Barriers and strategies to achieve a cure for HIV
9 years since the report of a cure for HIV after CC chemokine receptor type 5 Δ32 stem cell
transplantation, no other case of HIV cure has been reported, despite much research …
transplantation, no other case of HIV cure has been reported, despite much research …
HIV-1 latent reservoir size and diversity are stable following brief treatment interruption
DB Salantes, Y Zheng, F Mampe… - The Journal of …, 2018 - Am Soc Clin Investig
BACKGROUND. The effect of a brief analytical treatment interruption (ATI) on the HIV-1
latent reservoir of individuals who initiate antiretroviral therapy (ART) during chronic …
latent reservoir of individuals who initiate antiretroviral therapy (ART) during chronic …
Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial
TA Crowell, DJ Colby, S Pinyakorn, C Sacdalan… - The lancet HIV, 2019 - thelancet.com
Background HIV-1-specific broadly neutralising antibodies such as VRC01 could promote
HIV remission by halting viral replication and clearing infected cells. We investigated …
HIV remission by halting viral replication and clearing infected cells. We investigated …
HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers
HIV posttreatment controllers (PTCs) represent a natural model of sustained HIV remission,
but they are rare and little is known about their viral reservoir. We obtained 1,450 proviral …
but they are rare and little is known about their viral reservoir. We obtained 1,450 proviral …
Insight into treatment of HIV infection from viral dynamics models
The odds of living a long and healthy life with HIV infection have dramatically improved with
the advent of combination antiretroviral therapy. Along with the early development and …
the advent of combination antiretroviral therapy. Along with the early development and …
Chimeric antigen receptor T-cell approaches to HIV cure
AS Kuhlmann, CW Peterson… - Current Opinion in HIV and …, 2018 - journals.lww.com
Despite promising results in preclinical studies, only a handful of clinical trials have been
initiated worldwide. Several obstacles remain prior to successful application of HIV-specific …
initiated worldwide. Several obstacles remain prior to successful application of HIV-specific …