Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of
dramatic feats of regeneration, which have been studied for over 2 centuries. Recent …

Planarians are a group of flatworms. Some planarian species have remarkable regenerative
abilities, which involve abundant pluripotent adult stem cells. This makes these worms a …

INTRODUCTION Understanding the differentiation of stem cells into the vast amount of cell
types that form the human body is a central problem of basic and medical science. The …

INTRODUCTION The complete sequence of animal genomes has had a transformative
impact on biological research. Whereas the genome sequence of an organism contains the …

Proliferating cells known as neoblasts include pluripotent stem cells (PSCs) that sustain
tissue homeostasis and regeneration of lost body parts in planarians. However, the lack of …

Conventional gene expression studies analyze multiple cells simultaneously or single cells,
for which the exact in vivo or in situ position is unknown. Although cellular heterogeneity can …

Schistosomiasis is a neglected tropical disease that infects 240 million people. With no
vaccines and only one drug available, new therapeutic targets are needed. The causative …

Regeneration starts with injury. Yet how injuries affect gene expression in different cell types
and how distinct injuries differ in gene expression remain unclear. We defined the …

Planarian whole-body regeneration is enabled by stem cells called neoblasts. At least some
neoblasts are individually pluripotent. Neoblasts are also heterogeneous, with …

Many annelids can regenerate missing body parts or reproduce asexually, generating all
cell types in adult stages. However, the putative adult stem cell populations involved in these …