There is a continuous need for iterative cycles of antibiotic discovery and development to
deal with the selection of resistant pathogens that emerge as therapeutic application of an …

There is mounting urgency to find new drugs for the treatment of serious infectious diseases
and cancer that are rapidly developing resistance to previously effective drugs. One …

Using single-molecule fluorescence resonance energy transfer, we have defined bacterial
RNA polymerase (RNAP) clamp conformation at each step in transcription initiation and …

Drug-resistant bacterial pathogens pose an urgent public-health crisis. Here, we report the
discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibits …

Transcription, the first step of gene expression, is carried out by the enzyme RNA
polymerase (RNAP) and is regulated through interaction with a series of protein transcription …

With nearly one-third of the global population infected by Mycobacterium tuberculosis, TB
remains a major cause of death (1.7 million in 2006). TB is particularly severe in parts of …

A new drug target–the 'switch region'–has been identified within bacterial RNA polymerase
(RNAP), the enzyme that mediates bacterial RNA synthesis. The new target serves as the …

Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

Actinomycetes are remarkable producers of compounds essential for human and veterinary
medicine as well as for agriculture. The genomes of those microorganisms possess several …

Covering: up to the end of 2013 Myxobacteria produce a vast range of structurally diverse
natural products with prominent biological activities. Here, we provide a detailed description …