Regulated cell death in cancer: from pathogenesis to treatment

L Gong, D Huang, Y Shi, Z Liang, H Bu - Chinese Medical Journal, 2023 - mednexus.org
Regulated cell death (RCD), including apoptosis, pyroptosis, necroptosis, and ferroptosis, is
regulated by a series of evolutionarily conserved pathways, and is required for development …

Down-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-γ/JAK/STAT-1

S Wang, X Wang, J Sun, J Yang, D Wu, F Wu… - International Journal of …, 2023 - nature.com
Oral squamous cell carcinoma (OSCC) escape from the immune system is mediated through
several immunosuppressive phenotypes that are critical to the initiation and progression of …

IRF1 regulates the progression of colorectal cancer via interferon‑induced proteins

X Xu, Y Wu, K Yi, Y Hu, W Ding… - … journal of molecular …, 2021 - spandidos-publications.com
Radiation is one of the main methods for the treatment of colorectal cancer (CRC) before or
after surgery. However, radiotherapy tolerance of patients with CRC is often a major …

Radiosensitivity index emerges as a potential biomarker for combined radiotherapy and immunotherapy

YH Dai, YF Wang, PC Shen, CH Lo, JF Yang… - NPJ genomic …, 2021 - nature.com
In the era of immunotherapy, there lacks of a reliable genomic predictor to identify optimal
patient populations in combined radiotherapy and immunotherapy (CRI). The purpose of this …

Intertumoral genetic heterogeneity generates distinct tumor microenvironments in a novel murine synchronous melanoma model

SS Qin, BJ Han, A Williams, KM Jackson, R Jewell… - Cancers, 2021 - mdpi.com
Simple Summary Metastatic melanoma patients may present with multiple, simultaneous
metastases that are genetically different. This intertumoral heterogeneity can cause these …

Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction

E Maestri, K Duszka, VA Kuznetsov - Cancers, 2021 - mdpi.com
Simple Summary Dietary restriction regimens, such as caloric restriction (CR), in the
initiation and development of cancers has been studied using biological models and …