Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and
autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the …

Type-III interferons (IFN-λ, IFNL) are the most recently described family of IFNs. This family of
innate cytokines are increasingly being ascribed pivotal roles in host–pathogen interactions …

Background. Feedback mechanisms between interferons α and λ (IFNs) may be affected by
single nucleotide polymorphisms (SNP) in interleukin 28B (IL-28B; IFN-λ3) promoter region …

Genetic variants of the interferon lambda (IFNL) gene locus are strongly associated with
spontaneous and IFN treatment-induced clearance of hepatitis C virus (HCV) infections …

Many host-and vaccine-specific factors modulate an antibody response. Host genetic
polymorphisms, in particular, modulate the immune response in multiple ways on different …

Human IFN-λ4 is expressed by only a subset of individuals who possess the ΔG variant
allele at the dinucleotide polymorphism rs368234815. Recent genetic studies have shown …

Abstract Background Type III interferons (IFN), also called as lambda IFNs (IFN‐λs), are
antiviral and immunomodulatory cytokines that are evolutionarily important in humans …

Abstract Interferon (IFN) lambda (IFN-λ or type III IFN) gene polymorphisms were discovered
in the year 2009 to have a strong association with spontaneous and treatment-induced …

Abstract Interferon lambda 3 (IFN-λ3 or IFNL3, formerly IL28B), a type III interferon,
modulates immune responses during infection/inflammation. Several human studies have …