Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

Electrical stimulation of anterior nucleus of thalamus was effective for refractory focal
epilepsy in a clinical trial. The basic mechanisms of brain stimulation are understudied; …

Purpose: To investigate the effects of low frequency stimulation (LFS) of a fiber tract for the
suppression of spontaneous seizures in a rat model of human temporal lobe epilepsy …

It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility.
Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS …

Low frequency electrical stimulation (LFS) can reduce neural excitability and suppress
seizures in animals and patients with epilepsy. However the therapeutic outcome could …

Previously, we developed electroresponsive hydrogel nanoparticles (ERHNPs) modified
with angiopep-2 (ANG) to facilitate the delivery of the antiseizure drug phenytoin sodium …

Low-frequency stimulation (LFS) has been considered as an option for the treatment of
intractable epilepsy. However, previous data showed that LFS of certain brain regions only …

High-frequency stimulation (HFS) of the anterior nucleus of thalamus (ANT) is a new and
alternative option for the treatment of intractable epilepsy. However, the responder rate is …

Brain stimulation is an alternative treatment for epilepsy. However, the neuronal circuits
underlying its mechanisms remain obscure. We found that optogenetic activation (1Hz) of …

Objective. Closed-loop implantable neural stimulators are an exciting treatment option for
patients with medically refractory epilepsy, with a number of new devices in or nearing …