Born to run: control of transcription elongation by RNA polymerase II
FX Chen, ER Smith, A Shilatifard - Nature reviews Molecular cell …, 2018 - nature.com
The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …
integral part of the implementation of gene expression programmes during development. In …
The histone variant H2A. Z in gene regulation
BD Giaimo, F Ferrante, A Herchenröther, SB Hake… - Epigenetics & …, 2019 - Springer
The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …
[HTML][HTML] Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler
While nuclear compartmentalization is an essential feature of three-dimensional genome
organization, no genomic method exists for measuring chromosome distances to defined …
organization, no genomic method exists for measuring chromosome distances to defined …
Challenges in measuring and understanding biological noise
Biochemical reactions are intrinsically stochastic, leading to variation in the production of
mRNAs and proteins within cells. In the scientific literature, this source of variation is typically …
mRNAs and proteins within cells. In the scientific literature, this source of variation is typically …
MYC protein interactome profiling reveals functionally distinct regions that cooperate to drive tumorigenesis
Transforming members of the MYC family (MYC, MYCL1, and MYCN) encode transcription
factors containing six highly conserved regions, termed MYC homology boxes (MBs). By …
factors containing six highly conserved regions, termed MYC homology boxes (MBs). By …
Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation
The transition from transcription initiation to elongation is a key regulatory step in gene
expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing …
expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing …
CDK9-dependent RNA polymerase II pausing controls transcription initiation
S Gressel, B Schwalb, TM Decker, W Qin, H Leonhardt… - Elife, 2017 - elifesciences.org
Gene transcription can be activated by decreasing the duration of RNA polymerase II
pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we …
pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we …
The H2A. Z-nucleosome code in mammals: emerging functions
H2A. Z is a histone variant that provides specific structural and docking-side properties to the
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …
[HTML][HTML] MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”
High-intensity transcription and replication supercoil DNA to levels that can impede or halt
these processes. As a potent transcription amplifier and replication accelerator, the proto …
these processes. As a potent transcription amplifier and replication accelerator, the proto …
Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations
PR Cook, D Marenduzzo - Nucleic acids research, 2018 - academic.oup.com
Current models for the folding of the human genome see a hierarchy stretching down from
chromosome territories, through A/B compartments and topologically-associating domains …
chromosome territories, through A/B compartments and topologically-associating domains …