Pathogenesis of human immunodeficiency virus infection

JA Levy - Microbiological reviews, 1993 - Am Soc Microbiol
The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

Genotypic testing for human immunodeficiency virus type 1 drug resistance

RW Shafer - Clinical microbiology reviews, 2002 - Am Soc Microbiol
There are 16 approved human immunodeficiency virus type 1 (HIV-1) drugs belonging to
three mechanistic classes: protease inhibitors, nucleoside and nucleotide reverse …

Genetic Relationships Determined by a DNA Heteroduplex Mobility Assay: Analysis of HIV-1 env Genes

EL Delwart, EG Shpaer, J Louwagie, FE McCutchan… - Science, 1993 - science.org
The genetic diversity of human immunodeficiency virus (HIV) is a major concern thought to
impact on immunologic escape and eventual vaccine efficacy. Here, simple and rapid …

Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates

PD Kwong, R Wyatt, S Majeed, J Robinson, RW Sweet… - Structure, 2000 - cell.com
Background: The gp120 exterior envelope glycoprotein of HIV-1 binds sequentially to CD4
and chemokine receptors on cells to initiate virus entry. During natural infection, gp120 is a …

Genetic diversity of human immunodeficiency virus type 2: evidence for distinct sequence subtypes with differences in virus biology

F Gao, L Yue, DL Robertson, SC Hill, H Hui… - Journal of …, 1994 - Am Soc Microbiol
The virulence properties of human immunodeficiency virus type 2 (HIV-2) are known to vary
significantly and to range from relative attenuation in certain individuals to high-level …

The heterosexual human immunodeficiency virus type 1 epidemic in Thailand is caused by an intersubtype (A/E) recombinant of African origin

F Gao, DL Robertson, SG Morrison, H Hui… - Journal of …, 1996 - Am Soc Microbiol
Since 1989, human immunodeficiency virus type 1 (HIV-1) has spread explosively through
the heterosexual population in Thailand. This epidemic is caused primarily by viruses …

A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus …

K Hertogs, MP de Béthune, V Miller… - Antimicrobial agents …, 1998 - Am Soc Microbiol
Combination therapy with protease (PR) and reverse transcriptase (RT) inhibitors can
efficiently suppress human immunodeficiency virus (HIV) replication, but the emergence of …

Signature pattern analysis: a method for assessing viral sequence relatedness

B KORBER, G MYERS - AIDS research and human retroviruses, 1992 - liebertpub.com
Signature pattern analysis identifies particular sites in amino acid or nucleic acid alignments
of variable sequences that are distinctly representative of a query set of sequences relative …

Genetic differences between blood-and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: evidence of conserved elements …

BT Korber, KJ Kunstman, BK Patterson… - Journal of …, 1994 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) sequences were generated from blood and
from brain tissue obtained by stereotactic biopsy from six patients undergoing a diagnostic …

In vivo compartmentalization of human immunodeficiency virus: evidence from the examination of pol sequences from autopsy tissues

JK Wong, CC Ignacio, F Torriani, D Havlir… - Journal of …, 1997 - Am Soc Microbiol
High rates of mutation and replication of human immunodeficiency virus (HIV) allow for the
continuous generation of diverse genetic variants in vivo. Selective pressures within the …