Occurrence of metallothioneins (MTs) was initially thought to be restricted to the animal
kingdom, and the corresponding functions such as detoxification of heavy metal ions were …

The classical square planar transition metal complex cis-diamminodichlorido platinum
(II)(cisplatin) ranks among the most successful and widely applied antitumor drugs for the …

Metallothioneins (MTs) are a ubiquitous class of small metal-binding proteins involved in
metal homeostasis and detoxification. While known for their high affinity for d10 metal ions …

Dysregulation of copper and zinc homeostasis in the brain plays a critical role in Alzheimer
disease (AD). Copper binding to amyloid-β peptide (Aβ) is linked with the neurotoxicity of Aβ …

Abstract Cis-diamminedichloroplatinum (II)(cisplatin) is a widely used metal-based
chemotherapeutic drug for the treatment of cancers. However, intrinsic and acquired drug …

Intrinsic and acquired resistance are major drawbacks of platinum-based cancer therapy.
The protein superfamily of cysteine-and ZnII-rich proteins, metallothioneins (MT), efficiently …

The human copper-binding protein metallothionein-3 (MT-3) can reduce Cu (II) to Cu (I) and
form a polynuclear Cu (I) 4-Cys5–6 cluster concomitant with intramolecular disulfide bonds …

Background—Bicuspid aortic valve (BAV) is a heritable condition that has been linked by an
unknown mechanism to a predisposition for ascending aortic aneurysm. Matrix …

Metallothionein-3 (MT-3), also known as growth inhibitory factor (GIF), was originally
identified in the brain. An essential step in elucidating the potential roles of MT-3 is to …

Metallothioneins are ubiquitous low molecular mass, cysteine-rich proteins with an
extraordinary high metal ion content. In contrast to the situation for the vertebrate forms …