BACKGROUND AND OBJECTIVES: An imbalance in cytokine production may be involved
in the pathogenesis of chronic C hepatitis. The aim of the study was to investigate circulating …

Introduction: Liver fibrosis has been extensively studied at the cellular and molecular level,
but very few data exist on the final enzymatic stages of collagen synthesis (prolyl …

Hepatitis C virus (HCV) infection causes acute and chronic hepatitis, liver cirrhosis, and
hepatocellular carcinoma (HCC). However, the mechanisms by which HCV causes the …

An imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of
metalloproteinases (TIMPs) may contribute to liver fibrosis in patients with hepatitis C (HCV) …

OBJECTIVES: This study was aimed at searching noninvasive markers of the transition from
mild to severe fibrosis stage in HCV patients undergoing hepatic fibrosis. DESIGN AND …

Because of numerous limitations for liver biopsy, a noninvasive marker of liver cirrhosis is
sought. Promising indicators seem to be matrix metalloproteinases (MMPs) that are …

There are several causes of hepatocellular carcinoma (HCC), but certainly the hepatitis C
virus (HCV) is one of the most common. The HCV is able to contribute, both directly and …

Results: Serum PEDF and MMP-9 were higher in the study group than that in the control
group (P< 0.001). In patients with alcoholic or mixed (alcoholic and viral hepatitis-related) …

ABSTRACT Introduction: Mixed Cryoglobulinemia is the most frequent extrahepatic disease
in patients affected by Chronic Hepatitis C Virus infection. The association of pegylated …

Известно, что дисбаланс системы «протеолиз-антипротеолиз» является одним из
ключевых звеньев иммунофиброгенеза печени при хроническом гепатите С (ХГС). С …