Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

Calcitonin gene-related peptide (CGRP) has 37 amino acids. Initially, CGRP had
vasodilatory and nociceptive effects. As research progressed, evidence revealed that the …

SARS-CoV-2 is the etiological agent of COVID-19, an extremely heterogenous disease that
can cause severe respiratory failure and critical illness. To date, reliable biomarkers …

Background Calcitonin gene-related peptide (CGRP) is expressed throughout the body and
is a known mediator of migraine, exerting this biological effect through activation of …

Background In this study, we fill this gap in knowledge by updating the safety profile of
ubrogepant and rimegepant via disproportionality analysis in the Food and Drug …

Millions of people suffer from arthritis worldwide, consistently struggling with daily activities
due to debilitating pain evoked by this disease. Perhaps the most intensively investigated …

Background While growing evidence suggests a relationship between migraine and
cardiovascular disease, the genetic evidence for a causal relationship between migraine …

Background Hyperproliferation, inflammation, and mitochondrial abnormalities in pulmonary
artery smooth muscle cells (PASMCs) underlie the pathological mechanisms of vascular …

Göttingen Minipigs (GM) are used as an important preclinical model for cardiovascular
safety pharmacology and for evaluation of cardiovascular drug targets. To improve the …

Mechanical ventilation is an effective treatment for acute respiratory distress syndrome
(ARDS), which can improve the prognosis of ARDS to a certain extent. However, it may …