Adipose tissue inflammation and pulmonary dysfunction in obesity

G Palma, GP Sorice, VA Genchi, F Giordano… - International Journal of …, 2022 - mdpi.com
Obesity is a chronic disease caused by an excess of adipose tissue that may impair health
by altering the functionality of various organs, including the lungs. Excessive deposition of …

[HTML][HTML] The role of adipose tissue and nutrition in the regulation of adiponectin

S Baldelli, G Aiello, E Mansilla Di Martino, D Campaci… - Nutrients, 2024 - mdpi.com
Adipose tissue (AT), composed mainly of adipocytes, plays a critical role in lipid control,
metabolism, and energy storage. Once considered metabolically inert, AT is now recognized …

Leptin aggravates periodontitis by promoting M1 polarization via NLRP3

Y Han, Y Huang, P Gao, Q Yang, L Jia… - Journal of dental …, 2022 - journals.sagepub.com
Periodontitis is characterized by periodontal pocket formation, loss of attachment, and
alveolar bone resorption. Both innate and adaptive immunity are involved in the …

Role of NLRP3 inflammasome activation in obesity-mediated metabolic disorders

K Wani, H AlHarthi, A Alghamdi, S Sabico… - International journal of …, 2021 - mdpi.com
NLRP3 inflammasome is one of the multimeric protein complexes of the nucleotide-binding
domain, leucine-rich repeat (NLR)-containing pyrin and HIN domain family (PYHIN). When …

NLRP3 inflammasome activation in adipose tissues and its implications on metabolic diseases

KKL Wu, SWM Cheung, KKY Cheng - International Journal of Molecular …, 2020 - mdpi.com
Adipose tissue is an active endocrine and immune organ that controls systemic
immunometabolism via multiple pathways. Diverse immune cell populations reside in …

Recent insights on modulation of inflammasomes by adipokines: a critical event for the pathogenesis of obesity and metabolism-associated diseases

DV Pham, PH Park - Archives of pharmacal research, 2020 - Springer
Aberrant production of adipokines, a group of adipocytes-derived hormones, is considered
one of the most important pathological characteristics of obesity. In individuals with obesity …

Immunomodulatory Effects of a Low-Molecular Weight Polysaccharide from Enteromorpha prolifera on RAW 264.7 Macrophages and Cyclophosphamide- Induced …

Y Liu, X Wu, W Jin, Y Guo - Marine drugs, 2020 - mdpi.com
The water-soluble polysaccharide EP2, from Enteromorpha prolifera, belongs to the group of
polysaccharides known as glucuronoxylorhamnan, which mainly contains glucuronic acid …

Growth of breast cancer cells by leptin is mediated via activation of the inflammasome: Critical roles of estrogen receptor signaling and reactive oxygen species …

PK Raut, SH Kim, DY Choi, GS Jeong… - Biochemical pharmacology, 2019 - Elsevier
Leptin, a hormone primarily derived from adipose tissue, is known to induce tumor growth,
but its underlying mechanisms of action are not clearly understood. Inflammasomes, acting …

The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis

A Kulkarni, LW Bowers - Cellular and Molecular Life Sciences, 2021 - Springer
Obesity has been linked to an increased risk of and a worse prognosis for several types of
cancer. A number of interrelated mediators contribute to obesity's pro-tumor effects …

Exploring the role of the inflammasomes on prostate cancer: Interplay with obesity

JM Pérez-Gómez, AJ Montero-Hidalgo… - Reviews in Endocrine …, 2023 - Springer
Obesity is a weight-related disorder characterized by excessive adipose tissue growth and
dysfunction which leads to the onset of a systemic chronic low-grade inflammatory state …