Antibodies are key reagents to investigate cellular processes. The development of
recombinant antibodies and binders derived from natural protein scaffolds has expanded …

A popular and successful strategy in semi-rational design of protein stability is the use of
evolutionary information encapsulated in homologous protein sequences. Consensus …

A central question in protein evolution is the extent to which naturally occurring proteins
sample the space of folded structures accessible to the polypeptide chain. Repeat proteins …

Consensus sequence design offers a promising strategy for designing proteins of high
stability while retaining biological activity since it draws upon an evolutionary history in …

CTNNB1 (catenin β-1, also known as β-catenin) plays a dual role in the cell. It is the key
effector of WNT/CTNNB1 signalling, acting as a transcriptional co-activator of TCF/LEF target …

Antibodies have long been regarded as the only class of binding proteins. With the
emergence of protein engineering techniques, new binding proteins based on alternative …

Highlights•The most common interaction is a short, negatively-charged peptide binding
across a groove formed by two to three TPRs.•Longer peptides bind in an extended …

Peptide aptamers are small combinatorial proteins that are selected to bind to specific sites
on their target molecules. Peptide aptamers consist of short, 5-20 amino acid residues long …

Tandem repeat proteins, which are formed by repetition of modular units of protein
sequence and structure, play important biological roles as macromolecular binding and …

The emergence of novel binding proteins or antibody mimetics capable of binding to ligand
analytes in a manner analogous to that of the antigen–antibody interaction has spurred …