[HTML][HTML] Pyroptosis in inflammatory diseases and cancer
Z Rao, Y Zhu, P Yang, Z Chen, Y Xia, C Qiao, W Liu… - Theranostics, 2022 - ncbi.nlm.nih.gov
Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered
by inflammasomes and executed by gasdermin proteins. The main characteristics of …
by inflammasomes and executed by gasdermin proteins. The main characteristics of …
Targeting the NLRP3 inflammasome in cardiovascular diseases
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling …
L Luo, M Liu, Y Fan, J Zhang, L Liu, Y Li… - Journal of …, 2022 - Springer
Background Neuronal pyroptosis and neuroinflammation with excess microglial activation
are widely involved in the early pathological process of ischemic stroke. Repetitive …
are widely involved in the early pathological process of ischemic stroke. Repetitive …
Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease
The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …
The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …
DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …
during the reoxygenation phase following hypoxia, is well known in a variety of acute …
An overview of the molecular mechanisms associated with myocardial ischemic injury: state of the art and translational perspectives
L Schirone, M Forte, L D'Ambrosio, V Valenti… - Cells, 2022 - mdpi.com
Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …
cardiovascular diseases, myocardial infarction represents a life-threatening condition …
Guidelines for evaluating myocardial cell death
Cell death is a fundamental process in cardiac pathologies. Recent studies have revealed
multiple forms of cell death, and several of them have been demonstrated to underlie …
multiple forms of cell death, and several of them have been demonstrated to underlie …
Role of pyroptosis in cardiovascular diseases
Pyroptosis is a form of programmed necrosis, and is morphologically and mechanistically
unique form of programmed cell death compared to others, such as apoptosis and …
unique form of programmed cell death compared to others, such as apoptosis and …
Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice
R Yue, S Lu, Y Luo, J Zeng, H Liang, D Qin… - Cell death …, 2022 - nature.com
Recent evidence indicates that exosomes derived from mesenchymal stem cells (MSCs)
confer protective effects against myocardial ischemia/reperfusion (I/R) injury. Exosomes are …
confer protective effects against myocardial ischemia/reperfusion (I/R) injury. Exosomes are …