Endosomes, lysosomes and lysosome-related organelles are emerging as important Ca2+
storage cellular compartments with a central role in intracellular Ca2+ signalling …

Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate were discovered> 2
decades ago. That they are second messengers for mobilizing Ca 2+ stores has since been …

Lysosomes have traditionally been viewed as degradative organelles, although a growing
body of evidence suggests that they can function as Ca 2+ stores. Here we examined the …

Accumulating evidence implicates acidic organelles of the endolysosomal system as
mobilisable stores of Ca2+ but their relationship to the better-characterised endoplasmic …

Two-pore channels are endo-lysosomal cation channels with malleable selectivity filters that
drive endocytic ion flux and membrane traffic. Here we show that TPC2 can differentially …

Lysosomes and the endoplasmic reticulum (ER) are Ca 2+ stores mobilized by the second
messengers NAADP and IP 3, respectively. Here, we establish Ca 2+ signals between the …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is an agonist-generated second
messenger that releases Ca 2+ from intracellular acidic Ca 2+ stores. Recent evidence has …

To analyze the copper-induced cross talk among calcium, nitric oxide (NO), and hydrogen
peroxide (H2O2) and the calcium-dependent activation of gene expression, the marine alga …

Since the discovery of the Ca 2+ mobilizing effects of the pyridine nucleotide metabolite,
nicotinic acid adenine dinucleotide phosphate (NAADP), this molecule has been …

Disrupted cellular Ca2+ signaling is believed to play a role in a number of human diseases
including lysosomal storage diseases (LSD). LSDs are a group of∼ 50 diseases caused …