Chronic pain is long-lasting pain that often persists during chronic diseases or after recovery
from disease or injury. It often causes serious side effects, such as insomnia, anxiety, or …

Pain and anxiety comorbidities are a common health problem, but the neural mechanisms
underlying comorbidity remain unclear. We propose that comorbidity implies that similar …

Chronic neuropathic pain and comorbid depression syndrome (CDS) is a major worldwide
health problem that affects the quality of life of patients and imposes a tremendous …

The central mechanisms underlying pain chronicity remain elusive. Here, we identify a
reciprocal neuronal circuit in mice between the anterior cingulate cortex (ACC) and the …

Understanding how distinct functional circuits are coordinated to fine-tune mood and
behavior is of fundamental importance. Here, we observe that within the dense projections …

The nucleus accumbens (NAc) plays an important role in various emotional and motivational
behaviors that rely on heightened wakefulness. However, the neural mechanisms …

Peripheral inflammation is closely related to the pathogenesis of sickness behaviors and
psychiatric disorders such as anxiety and depression. The circumventricular organs (CVOs) …

Abstract Purpose of Review This review critically analyzes the recent literature on virtual
reality's (VR) use in acute and chronic pain management, offering insights into its efficacy …

Complex pathophysiology in psychiatric disorders results in difficulties interpreting pre-
clinical data. Guilloux et al.(2011b), proposed an integrated behavioural z-scoring …

Previous studies have shown that ligands that bind to sigma-2 receptor/TMEM97
(s2R/TMEM97), a transmembrane protein, have anxiolytic/antidepressant-like properties …