Viruses have a dual nature: particles are “passive substances” lacking chemical energy
transformation, whereas infected cells are “active substances” turning-over energy. How …

Since the early 1990s, single-molecule detection in solution at room temperature has
enabled direct observation of single biomolecules at work in real time and under …

Many of the biological functions of a cell are dictated by the intricate motion of proteins within
its membrane over a spatial range of nanometres to tens of micrometres and time intervals of …

Molecular interactions are often transient and might change within the window of
observation, leading to changes in molecule movement. Therefore, accurate motion analysis …

Derailed transmembrane receptor trafficking could be a hallmark of tumorigenesis and
increased tumor invasiveness, but receptor dynamics have not been used to differentiate …

Real‐time feedback‐driven single‐particle tracking (RT‐FD‐SPT) is a class of techniques in
the field of single‐particle tracking that uses feedback control to keep a particle of interest in …

Nanoparticle (NP)-based targeted drug delivery is intended to transport therapeutically
active molecules to specific cells and particular intracellular compartments. However, there …

Here, we present a three-dimensional two-color dual-particle tracking (3D-2C-DPT)
technique that can simultaneously localize two spectrally distinct targets in three dimensions …

Lanthanide-doped upconversion nanoparticles (UCNPs) are inorganic nanomaterials in
which the lanthanide cations embedded in the host matrix can convert incident near-infrared …

Single-molecule detection enables direct characterization of annealing/melting kinetics of
nucleic acids without the need for synchronization of molecular states, but the current …