Here we review the applications of atomic force microscopy to the study of samples of
biological origin. Emphasis is given to provide the reader with information on the broad …

The ability to evaluate structural–functional relationships in real time has allowed scanning
probe microscopy (SPM) to assume a prominent role in post genomic biological research. In …

MicroRNAs play important roles in regulating the gene expression and life cycle of cancer
cells. In particular, miR-21, an oncogenic miRNA is a major player involved in tumor …

β-Amyloid (Aβ) acquires toxicity by self-aggregation. To identify and characterize the toxic
form (s) of Aβ aggregates, we examined in vitro aggregation conditions by using large …

Tertiary structure of supercoiled DNA is a significant factor in a number of genetic functions
and is apparently affected by environmental conditions. We applied atomic force microscopy …

In buffers containing selected transition metal salts, DNA binds to mica tightly enough to be
directly imaged in the buffer in the atomic force microscope (AFM, also known as scanning …

The procedure of surface functionalization based on the use of 1-(3-Aminopropyl) silatrane
(APS) instead of our early procedure utilizing aminopropyl triethoxy silane (APTES) is …

Modulation of immune response is important in cancer immunotherapy, vaccine adjuvant
development and inflammatory or immune disease therapy. Here we report the development …

The nature of DNA adsorption to various substrates has been investigated by atomic force
microscopy. The substrates used were mica, silylated mica, calcite, fluorite, and barite. The …

We have obtained striking atomic force microscopy images of the intact lambda
bacteriophage genome and of several lambda restriction fragments both in air and under …