All lifeforms have developed highly sophisticated systems equipped to detect altered self
and non-self nucleic acids (NA). In vertebrates, NA-sensing receptors safeguard the integrity …

Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …

The term 'nonsense-mediated mRNA decay'(NMD) was initially coined to describe the
translation-dependent degradation of mRNAs harboring premature termination codons …

The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs
harboring premature termination codons (PTCs) but also regulates the abundance of a large …

Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mechanism that
monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature …

Here, we present a potent RNA vaccine approach based on a novel bipartite vector system
using trans-amplifying RNA (taRNA). The vector cassette encoding the vaccine antigen …

The compendium of RNA-binding proteins (RBPs) has been greatly expanded by the
development of RNA-interactome capture (RIC). However, it remained unknown if the …

Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance
pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical …

RNA silencing is a fundamental, evolutionarily conserved mechanism that regulates gene
expression in eukaryotes. It also functions as a primary immune defense in microbes, such …

Nonsense‐mediated mRNA decay (NMD) was originally coined to define a quality control
mechanism that targets mRNAs with truncated open reading frames due to the presence of a …