Ovarian cancer (OC) is an aggressive gynecological tumor usually diagnosed with
widespread metastases and ascites. Here, we depicted a single-cell landscape of the OC …

Foxp3-expressing CD25+ CD4+ regulatory T cells (Tregs) are abundant in tumor tissues.
Here, hypothesizing that tumor Tregs would clonally expand after they are activated by …

The T cell receptor (TCR) endows T cells with antigen specificity and is central to nearly all
aspects of T cell function. Each naïve T cell has a unique TCR sequence that is stably …

Simple Summary Antibodies directed at so-called immune checkpoint molecules represent a
substantial improvement in cancer therapy. These biological reagents highlight the exquisite …

Regulatory T cells (Treg) are conventionally viewed as suppressors of endogenous and
therapy-induced antitumor immunity; however, their role in modulating responses to immune …

The presence of T regulatory (Treg) cells in the tumor microenvironment is associated with
poor prognosis and resistance to therapies aimed at reactivating anti-tumor immune …

Orchestration of an effective T lymphocyte response at infection sites is critical for protection
against Mycobacterium tuberculosis (Mtb) infection. However, the local T cell immunity …

Regulatory T cells (Tregs) contribute to the formation of a tumor-immunosuppressive
microenvironment. CCR8 is reportedly selectively expressed in tumor Tregs, and an anti …

Chimeric antigen receptor (CAR) T cells used for the treatment of B cell malignancies can
identify T cell subsets with superior clinical activity. Here, using infusion products of …

Malignant melanoma is a major public health issue displaying frequent resistance to
targeted therapy and immunotherapy. A major challenge lies in better understanding how …