COVID-19 convalescent plasma and clinical trials: understanding conflicting outcomes

D Focosi, M Franchini, L Pirofski… - Clinical microbiology …, 2022 - Am Soc Microbiol
Convalescent plasma (CP) recurs as a frontline treatment in epidemics because it is
available as soon as there are survivors. The COVID-19 pandemic represented the first …

Replicating viral vector-based vaccines for COVID-19: potential avenue in vaccination arena

VP Chavda, R Bezbaruah, M Athalye, PK Parikh… - Viruses, 2022 - mdpi.com
The “severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)” is the third member of
human coronavirus (CoV) that is held accountable for the current “coronavirus disease 2019 …

Association of convalescent plasma treatment with clinical status in patients hospitalized with COVID-19: a meta-analysis

AB Troxel, E Petkova, K Goldfeld, M Liu… - JAMA Network …, 2022 - jamanetwork.com
Importance COVID-19 convalescent plasma (CCP) is a potentially beneficial treatment for
COVID-19 that requires rigorous testing. Objective To compile individual patient data from …

Convalescent plasma associates with reduced mortality and improved clinical trajectory in patients hospitalized with COVID-19

SAA Egloff, A Junglen, JSA Restivo… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND Evidence supporting convalescent plasma (CP), one of the first
investigational treatments for coronavirus disease 2019 (COVID-19), has been inconclusive …

A phase 2 single center open label randomised control trial for convalescent plasma therapy in patients with severe COVID-19

Y Ray, SR Paul, P Bandopadhyay, R D'Rozario… - Nature …, 2022 - nature.com
A single center open label phase 2 randomised control trial (Clinical Trial Registry of India
No. CTRI/2020/05/025209) was done to assess clinical and immunological benefits of …

Coinfections and superinfections associated with COVID-19 in Colombia: A narrative review

D Dueñas, J Daza, Y Liscano - Medicina, 2023 - mdpi.com
The COVID-19 pandemic has had significant impacts on healthcare systems around the
world, including in Latin America. In Colombia, there have been over 23,000 confirmed …

Next-generation serology by mass spectrometry: readout of the SARS-CoV-2 antibody repertoire

RD Melani, BJ Des Soye, JO Kafader… - Journal of proteome …, 2021 - ACS Publications
Methods of antibody detection are used to assess exposure or immunity to a pathogen.
Here, we present Ig-MS, a novel serological readout that captures the immunoglobulin (Ig) …

Hyperimmune Plasma and Immunoglobulins against COVID-19: a narrative review

M Franchini, D Focosi - Life, 2024 - mdpi.com
Since late 2019, the new SARS-CoV-2 virus belonging to the Coronaviridae family has been
responsible for COVID-19 pandemic, a severe acute respiratory syndrome. Several antiviral …

Convalescent plasma and COVID‐19: Time for a second—second look?

MJ Joyner, RE Carter, DL Fairweather… - Transfusion …, 2023 - Wiley Online Library
In this short narrative, we highlight some of our experiences leading the US Convalescent
Plasma Program at the beginning of the pandemic in the spring and summer of 2020. This …

Inflammatory markers and auto-Abs to type I IFNs in COVID-19 convalescent plasma cohort study

F Cognasse, H Hamzeh-Cognasse, M Rosa… - …, 2023 - thelancet.com
Background COVID-19 convalescent plasma (CCP) contains neutralising anti-SARS-CoV-2
antibodies that may be useful as COVID-19 passive immunotherapy in patients at risk of …