Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated
diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings …

Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Alterations in the composition of the intestinal microbiota have been correlated with aging
and measures of frailty in the elderly. However, the relationships between microbial …

Growth and differentiation factor 15 (GDF15) belongs to the transforming growth factor-β
(TGF-β) superfamily of proteins. Glial-derived neurotrophic factor (GDNF) family receptor α …

Women live on average longer than men but have greater levels of late-life morbidity. We
have uncovered a substantial sex difference in the pathology of the aging gut in Drosophila …

Regenerative processes that maintain the function of the gastrointestinal (GI) epithelium are
critical for health and survival of multicellular organisms. In insects and vertebrates, intestinal …

The quest to extend healthspan via pharmacological means is becoming increasingly
urgent, both from a health and economic perspective. Here we show that lithium, a drug …

All people want to age “successfully,” maintaining functional capacity and quality of life as
they reach advanced age. Achieving this goal depends on preserving optimal cognitive and …

The accumulation of damage caused by oxidative stress has been linked to aging and to the
etiology of numerous age-related diseases. The longevity gene, sirtuin 6 (SIRT6), promotes …

Neurodegeneration in the central nervous system (CNS) is a defining feature of organismal
aging that is influenced by peripheral tissues. Clinical observations indicate that skeletal …