RNase T1 is the best known representative of a large family of ribonucleolytic proteins
secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among …

Peptides and proteins with antimicrobial activity are produced throughout all kingdoms in
nature, from prokaryotes to lower and higher eukaryotes, including fungi, plants …

Filamentous fungal pathogens secrete effectors that modulate host immunity and facilitate
infection. Fusarium graminearum is an important plant pathogen responsible for various …

α‐Sarcin is a ribosome‐inactivating protein that has been well characterized in vitro, but little
is known about its toxicity in living cells. We have analyzed the mechanism of internalization …

α-Sarcin selectively cleaves a single phosphodiester bond in a universally conserved
sequence of the major rRNA, that inactivates the ribosome. The elucidation of the three …

A single-chain fusion protein that directed the cytolytic activity of α-sarcin to A33 tumor
antigen expressing cells was constructed and shown to effectively kill targeted cells …

Elsewhere in this volume, 1 it was mentioned that it would be interesting to insert the
targeting motifs of ribotoxins (presumably responsible for the ability to gain access to the …

Entomopathogenic fungi are promising bio-pesticides. To facilitate infection, fungi recruit
multiple virulence factors and deploy different molecular strategies to evade host immunity …

The electrostatic behavior of titrating groups in α-sarcin was investigated using 1H NMR
spectroscopy. A total of 209 chemical shift titration curves corresponding to different protons …

The pestivirus envelope glycoprotein E rns has RNase activity and therefore was suspected
to enter cells to cleave RNA. The protein contains an RNase domain with a C-terminal …