Cell cultures are important material of study for the variety of advantages that they offer. Both
established continuous cell lines and primary cell cultures continue to be invaluable for …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of
functions in the body, including homeostasis, synthesis of essential components, nutrient …

In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined
to develop bioartificial substitutes for organs and tissues, which can in turn be applied in …

Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a
significant challenge for the pharmaceutical and chemical industries. Generally …

Two-dimensional (2D) monolayer cultures are the standard in vitro model for cancer
research. However, they fail to recapitulate the three-dimensional (3D) environment and …

Advances in three-dimensional (3D) printing techniques and the development of tailored
biomaterials have facilitated the precise fabrication of biological components and complex …

Since the 1970s, the limitations of two dimensional (2D) cell culture and the relevance of
appropriate three dimensional (3D) cell systems have become increasingly evident …

Life science research focuses on deciphering the biochemical mechanisms that regulate cell
proliferation and function and largely depends on the use of tissue culture methods in which …

Glioblastoma (GBM) is the most common primary malignant central nervous system tumor.
The current treatment is mainly surgical resection combined with radiotherapy …