Advances in hypoxia-inducible factor biology
H Choudhry, AL Harris - Cell metabolism, 2018 - cell.com
Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …
History, discovery, and classification of lncRNAs
J Jarroux, A Morillon, M Pinskaya - Long non coding RNA biology, 2017 - Springer
Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …
The Landscape of long noncoding RNA classification
GS Laurent, C Wahlestedt, P Kapranov - Trends in genetics, 2015 - cell.com
Advances in the depth and quality of transcriptome sequencing have revealed many new
classes of long noncoding RNAs (lncRNAs). lncRNA classification has mushroomed to …
classes of long noncoding RNAs (lncRNAs). lncRNA classification has mushroomed to …
Non-coding RNAs regulation of macrophage polarization in cancer
Noncoding RNA (ncRNA) transcripts that did not code proteins but regulate their functions
were extensively studied for the last two decades and the plethora of discoveries have …
were extensively studied for the last two decades and the plethora of discoveries have …
Noncoding RNAs in extracellular fluids as cancer biomarkers: the new frontier of liquid biopsies
The last two decades of cancer research have been devoted in two directions:(1)
understanding the mechanism of carcinogenesis for an effective treatment, and (2) …
understanding the mechanism of carcinogenesis for an effective treatment, and (2) …
High-throughput annotation of full-length long noncoding RNAs with capture long-read sequencing
Accurate annotation of genes and their transcripts is a foundation of genomics, but currently
no annotation technique combines throughput and accuracy. As a result, reference gene …
no annotation technique combines throughput and accuracy. As a result, reference gene …
Junk DNA and the long non-coding RNA twist in cancer genetics
The central dogma of molecular biology states that the flow of genetic information moves
from DNA to RNA to protein. However, in the last decade this dogma has been challenged …
from DNA to RNA to protein. However, in the last decade this dogma has been challenged …
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is
common in many types of cancer, and generally confers a poor prognosis. Known to induce …
common in many types of cancer, and generally confers a poor prognosis. Known to induce …
Basic biology and therapeutic implications of lncRNA
O Khorkova, J Hsiao, C Wahlestedt - Advanced drug delivery reviews, 2015 - Elsevier
Long non-coding RNAs (lncRNA), a class of non-coding RNA molecules recently identified
largely due to the efforts of FANTOM, and later GENCODE and ENCODE consortia, have …
largely due to the efforts of FANTOM, and later GENCODE and ENCODE consortia, have …
The lncRNA HOTAIRM1 regulates the degradation of PML-RARA oncoprotein and myeloid cell differentiation by enhancing the autophagy pathway
ZH Chen, WT Wang, W Huang, K Fang… - Cell Death & …, 2017 - nature.com
Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are of great
importance in different cell contexts. However, only a very small number of lncRNAs have …
importance in different cell contexts. However, only a very small number of lncRNAs have …