Ewing sarcoma (ES) is a highly aggressive bone and soft-tissue tumor with peak incidence
among adolescents and young adults. Despite advances in local control and systemic …

The emergence during evolution of two tumour necrosis factor (TNF)-related apoptosis-
inducing ligand (TRAIL) receptors, receptor-1/DR4 and-2/DR5, able to induce apoptosis has …

Bone sarcomas are rare, highly malignant mesenchymal tumours that affect teenagers and
young adults, as well as older patients. Despite intensive, multimodal therapy, patients with …

Apoptosis functions as a common mechanism to eliminate unnecessary or damaged cells
during cell renewal and tissue development in multicellular organisms. More than 200 …

The European Network for Cancer Research in Children and Adolescents (ENCCA)
provides an interaction platform for stakeholders in research and care of children with …

Receptor activator of nuclear factor‐κB (RANK) and RANK ligand (RANKL) play a pivotal
role in bone metabolism, and selective targeting of RANK signaling has become a promising …

Abstract Desmoplastic Small Round Cell Tumor (DSRCT) is a rare sarcoma tumor of
adolescence and young adulthood, which harbors a recurrent chromosomal translocation …

Simple Summary Osteosarcoma and Ewing sarcoma are the two most common malignant
primary bone tumors occurring during childhood. These highly aggressive cancers are still …

The tumour necrosis factor (TNF) ligand family member TNF-related apoptosis-inducing
ligand (TRAIL) induces apoptosis predominantly in tumour cells, but not in normal tissues …

Background: Despite good initial response to chemotherapy, 30% of Ewing's sarcoma
(EWS) patients with localised tumours develop recurrent disease, associated with poor …