Unfolding the complexity of epigenetics in male reproductive aging: a review of therapeutic implications

AF Ajayi, MO Oyovwi, G Olatinwo, AO Phillips - Molecular Biology Reports, 2024 - Springer
Introduction: Epigenetics studies gene expression changes influenced by environmental
and lifestyle factors, linked to health conditions like reproductive aging. Male reproductive …

Human brain organoids for understanding substance use disorders

K Li, L Gu, H Cai, HC Lu, K Mackie, F Guo - Drug metabolism and …, 2024 - Elsevier
Substance use disorders (SUDs) are complex mental health conditions involving a
problematic pattern of substance use. Challenges remain in understanding its neural …

From powerhouse to regulator: The role of mitoepigenetics in mitochondrion-related cellular functions and human diseases

L Donato, D Mordà, C Scimone, S Alibrandi… - Free Radical Biology …, 2024 - Elsevier
Beyond their crucial role in energy production, mitochondria harbor a distinct genome
subject to epigenetic regulation akin to that of nuclear DNA. This paper delves into the …

Advancing microbiota therapeutics: the role of synthetic biology in engineering microbial communities for precision medicine

A Nazir, FHN Hussain, A Raza - Frontiers in Bioengineering and …, 2024 - frontiersin.org
Over recent years, studies on microbiota research and synthetic biology have explored
novel approaches microbial manipulation for therapeutic purposes. However, fragmented …

The Histone Lysine Demethylase KDM7A Contributes to Reward Memory via Fscn1‐Induced Synaptic Plasticity in the Medial Prefrontal Cortex

Z Yang, D Yu, F Gao, D Zhou, Y Wu, X Yang… - Advanced …, 2025 - Wiley Online Library
Abstract Lysine demethylase 7A (KDM7A) catalyzes the removal of dimethylation from
histone H3 lysine 9 and lysine 27, both of which are associated with transcription repression …

Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal

SN Wani, AK Grewal, H Khan, TG Singh - Psychopharmacology, 2024 - Springer
The persistent use of opioids leads to profound changes in neuroplasticity of the brain,
contributing to the emergence and persistence of addiction. However, chronic opioid use …

Neuroscience and addiction research: current advances and perspectives

E Darcq, BL Kieffer - Journal of Neural Transmission, 2024 - Springer
E. Darcq, BL Kieffer tools to causally link gene function and behavior in addition research
(Charbogne et al. 2014; Darcq and Kieffer 2018; Jordan and Xi 2021; Neasta et al. 2020) …

[HTML][HTML] Visiones de estudiantes universitarios sobre las drogas adictivas y el ambiente educativo

LG Jiménez-Herrera - Formación universitaria, 2024 - SciELO Chile
El objetivo de esta investigación es examinar la percepción de estudiantes de la
Universidad de Costa Rica con relación a drogas adictivas. Se realiza un estudio cualitativo …

Features of Opioid Use Disorder: Interlinking Transcriptomics, Epigenetics, and Postmortem Studies Highlight Opioid-Induced Neurovascular Alterations

C Walss-Bass - Handbook of the Biology and Pathology of Mental …, 2024 - Springer
Epigenetic modifications, including DNA methylation and microRNAs, play an important role
in modulating the risk for opioid use disorder and in mediating the consequences of this …

Význam epigenetických mechanismů při rozvoji drogové závislosti

M Durdilová - 2024 - dspace.cuni.cz
Zneužívání návykových látek je celosvětově velice rozšířené a nese s sebou řadu
negativních dopadů, jak na jednotlivce, tak na okolí. Na některé látky může vznikat závislost …