NLRP3 inflammasome, an immune‐inflammatory target in pathogenesis and treatment of cardiovascular diseases

Y Wang, X Liu, H Shi, Y Yu, Y Yu, M Li… - Clinical and …, 2020 - Wiley Online Library
Inflammation is an important process involved in several cardiovascular diseases (CVDs),
and nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a vital …

Pyroptosis: a new regulating mechanism in cardiovascular disease

N Ji, Z Qi, Y Wang, X Yang, Z Yan, M Li… - Journal of …, 2021 - Taylor & Francis
Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and
apoptosis, pyroptosis has unique characteristics in morphology and mechanism …

[HTML][HTML] METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications

D Jian, Y Wang, L Jian, H Tang, L Rao, K Chen… - Theranostics, 2020 - ncbi.nlm.nih.gov
Aims: The N6-methyladenosine (m 6 A) modification plays an important role in various
biological processes, but its role in atherosclerosis remains unknown. The aim of this study …

[HTML][HTML] Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis

Y Jin, Y Liu, L Xu, J Xu, Y Xiong, Y Peng, K Ding… - Cell death & …, 2022 - nature.com
Atherosclerosis is a maladaptive chronic inflammatory disease, which remains the leading
cause of death worldwide. The NLRP3 inflammasome constitutes a major driver of …

Butyrate-producing bacteria and the gut-heart axis in atherosclerosis

W Chen, S Zhang, J Wu, T Ye, S Wang, P Wang… - Clinica chimica acta, 2020 - Elsevier
The gut microbiota plays an important role in controlling atherosclerosis progression to
support the link between the gut and coronary heart disease. Recent studies have shown …

Foam cells: one size doesn't fit all

V Guerrini, ML Gennaro - Trends in immunology, 2019 - cell.com
Chronic inflammation in many infectious and metabolic diseases, and some cancers, is
accompanied by the presence of foam cells. These cells form when the intracellular lipid …

Quercetin attenuates atherosclerotic inflammation by inhibiting galectin‐3‐NLRP3 signaling pathway

H Li, L Xiao, H He, H Zeng, J Liu… - Molecular nutrition & …, 2021 - Wiley Online Library
Scope Atherosclerosis is the underlying pathogenesis of cardiovascular events caused by
inflammation, and dietary intervention has been recommended as one fundamental …

Oxidative stress biomarker triggered multiplexed tool for auxiliary diagnosis of atherosclerosis

Y Ma, W Sun, Z Ye, L Liu, M Li, J Shang, X Xu… - Science …, 2023 - science.org
Oxidative stress is integral in the development of atherosclerosis, but knowledge of how
oxidative stress affects atherosclerosis remains insufficient. Here, we design a multiplexed …

Ketone body 3‐hydroxybutyrate ameliorates atherosclerosis via receptor Gpr109a‐mediated calcium influx

S Zhang, Z Li, Y Zhang, J Chen, Y Li, F Wu… - Advanced …, 2021 - Wiley Online Library
Atherosclerosis is a chronic inflammatory disease that can cause acute cardiovascular
events. Activation of the NOD‐like receptor family, pyrin domain containing protein 3 …

The role of NLRP3 inflammasome in cerebrovascular diseases pathology and possible therapeutic targets

R Bai, Y Lang, J Shao, Y Deng, R Refuhati… - ASN neuro, 2021 - journals.sagepub.com
Cerebrovascular diseases are pathological conditions involving impaired blood flow in the
brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid …