Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Cell death pathways have evolved to maintain tissue homoeostasis and eliminate potentially
harmful cells from within an organism, such as cells with damaged DNA that could lead to …

All life ends in death, but perhaps one of life's grander ironies is that it also depends on
death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for …

Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …

TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine
production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α …

This article is part of a Minifocus on Ubiquitin. For further reading, please see related
articles: ʻUbiquitin and SUMO in DNA repair at a glanceʼ by Helle D. Ulrich (J. Cell Sci …

A better understanding of the mechanisms through which anticancer drugs exert their effects
is essential to improve combination therapies. While studying how genotoxic stress kills …

E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating
transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate. The activity of …

Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed
by proteases called caspases. The Bcl2 family of intracellular proteins is the central …