Sepsis is a heterogeneous disease state that is both common and consequential in critically
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …

Sepsis is a clinical syndrome defined by physiologic changes indicative of systemic
inflammation, which are likely attributable to documented or suspected infection. Septic …

Biomarkers have great potential to improve the diagnosis and treatment of sepsis. The
available literature supports the potential utility of sTREM-1, IL-27, suPAR, neutrophil CD64 …

Introduction The intrinsic heterogeneity of clinical septic shock is a major challenge. For
clinical trials, individual patient management, and quality improvement efforts, it is unclear …

Sepsis in children | The BMJ Skip to main content Intended for healthcare professionals
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Several biochemical markers have been proposed over the past years to manage critically ill
newborns with acute inflammation and sepsis. The state of the art in diagnosing and …

Purpose Early accurate diagnosis of infection±organ dysfunction (sepsis) remains a major
challenge in clinical practice. Utilizing effective biomarkers to identify infection and …

Objective: The Pediatric Sepsis Biomarker Risk Model (PERSEVERE), a pediatric sepsis risk
model, uses biomarkers to estimate baseline mortality risk for pediatric septic shock. It is …

Sepsis is a complex inflammatory response to infection. Microarray-based gene expression
studies of sepsis have illuminated the complex pathogen recognition and inflammatory …

Objectives: Clinical trials in septic shock continue to fail due, in part, to inequitable and
sometimes unknown distribution of baseline mortality risk between study arms. Investigators …