CD4 T-cell exhaustion: does it exist and what are its roles in cancer?
In chronic infections and in cancer, persistent antigen stimulation under suboptimal
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
T cell allorecognition pathways in solid organ transplantation
JHY Siu, V Surendrakumar, JA Richards… - Frontiers in …, 2018 - frontiersin.org
Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct
pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; …
pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; …
Resident memory T cells in the skin mediate durable immunity to melanoma
BT Malik, KT Byrne, JL Vella, P Zhang… - Science …, 2017 - science.org
Tissue-resident memory T (TRM) cells have been widely characterized in infectious disease
settings; however, their role in mediating immunity to cancer remains unknown. We report …
settings; however, their role in mediating immunity to cancer remains unknown. We report …
Programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) regulate CD4+ T cells to induce Type 2 helper T cell (Th2) bias at the maternal–fetal …
SC Wang, XY Zhu, YY Xu, D Zhang, YH Li… - Human …, 2016 - academic.oup.com
STUDY QUESTION Are the immune regulatory molecules programmed cell death-1 (PD-1)
and T-cell immunoglobulin mucin-3 (Tim-3) involved in regulating CD4+ T cell function …
and T-cell immunoglobulin mucin-3 (Tim-3) involved in regulating CD4+ T cell function …
[HTML][HTML] T-cell exhaustion correlates with improved outcomes in kidney transplant recipients
M Fribourg, L Anderson, C Fischman, C Cantarelli… - Kidney international, 2019 - Elsevier
Continuous antigen stimulation during chronic infection or malignancy can promote
functional T cell silencing, a phenomenon called T cell exhaustion. The prevalence and …
functional T cell silencing, a phenomenon called T cell exhaustion. The prevalence and …
Exhausted and senescent T cells at the maternal‐fetal interface in preterm and term labor
Successful pregnancy requires a tightly‐regulated equilibrium of immune cell interactions at
the maternal‐fetal interface (ie, the decidual tissues), which plays a central role in the …
the maternal‐fetal interface (ie, the decidual tissues), which plays a central role in the …
Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice
E Sula Karreci, H Fan, M Uehara… - Proceedings of the …, 2016 - National Acad Sciences
Constitutive proteasomes (c-20S) are ubiquitously expressed cellular proteases that
degrade polyubiquitinated proteins and regulate cell functions. An isoform of proteasome …
degrade polyubiquitinated proteins and regulate cell functions. An isoform of proteasome …
Diet-induced obesity exacerbates imiquimod-mediated psoriasiform dermatitis in anti-PD-1 antibody-treated mice: Implications for patients being treated with …
Background An ever-increasing number of cancer patients are being treated with checkpoint
inhibitors such as anti-PD-1 antibodies, and a small percentage of these patients develop a …
inhibitors such as anti-PD-1 antibodies, and a small percentage of these patients develop a …
An emerging role of TIM3 expression on T cells in chronic kidney inflammation
C Lu, H Chen, C Wang, F Yang, J Li, H Liu… - Frontiers in …, 2022 - frontiersin.org
T cell immunoglobulin domain and mucin domain 3 (TIM3) was initially identified as an
inhibitory molecule on IFNγ-producing T cells. Further research discovered the broad …
inhibitory molecule on IFNγ-producing T cells. Further research discovered the broad …
Pigs expressing the human inhibitory ligand PD‐L1 (CD 274) provide a new source of xenogeneic cells and tissues with low immunogenic properties
A Buermann, S Petkov, B Petersen, R Hein… - …, 2018 - Wiley Online Library
Background The programmed cell death‐1 (PD‐1, CD 279)/PD‐Ligand1 (PD‐L1, CD 274)
receptor system is crucial for controlling the balance between immune activation and …
receptor system is crucial for controlling the balance between immune activation and …