Pharmacophore modeling, 3D‐QSAR, synthesis, and anti‐lung cancer evaluation of novel thieno[2,3‐d][1,2,3]triazines targeting EGFR
Abstract Two series of thieno [2, 3‐d][1, 2, 3] triazine derivatives were designed, synthesized,
and biologically evaluated as potential epidermal growth factor receptor (EGFR) inhibitors …
and biologically evaluated as potential epidermal growth factor receptor (EGFR) inhibitors …
Pharmacophore‐based, rationale design, and efficient synthesis of novel tetrahydrobenzo[b]thiophene candidates as potential dual Topo I/II inhibitors and DNA …
HR Nofal, AA Al‐Karmalawy, AA Elmaaty… - Archiv der …, 2024 - Wiley Online Library
A series of tetrahydrobenzo [b] thiophene derivatives was designed and synthesized as dual
topoisomerase (Topo) I/II inhibitors implicating potential DNA intercalation. Ethyl‐2‐amino‐3 …
topoisomerase (Topo) I/II inhibitors implicating potential DNA intercalation. Ethyl‐2‐amino‐3 …
Studies on synthesis and reactions of some new five and six-membered heterocycles bearing 5, 6, 7, 8-tetrahydrobenzo [b] thieno [2, 3-d] pyrimidin-4 (3H)-ones …
Thienopyrimidine derivatives are well-known in various pharmaceutical and biomedical
domains. In this work, a series of efficacious and novel strategies for the synthesis of …
domains. In this work, a series of efficacious and novel strategies for the synthesis of …
[PDF][PDF] Конструирование биологически активных производных 7-метил-5, 6, 7, 8-тетрагидро [1] бензотиено [2, 3-d] пиримидин-4 (3Н)-она
И Бабанассер - 2023 - dspace.nuph.edu.ua
АННОТАЦИЯ Запланирован и рационально проведен синтез потенциально
биологически активных 2-S-алкил производных 7-метил-5, 6, 7, 8-тетрагидро [1] …
биологически активных 2-S-алкил производных 7-метил-5, 6, 7, 8-тетрагидро [1] …
Síntese, elucidação estrutural e estudos in silico de novos compostos 2-amino-tiofênicos imídicos candidatos a fármacos antifúngicos, antileishmanicida e …
ALC Pereira - 2019 - repositorio.ufpb.br
UNIVERSIDADE FEDERAL DA PARAÍBA PROGRAMA DE PÓS-GRADUAÇÃO EM
PRODUTOS NATURAIS E SINTÉTICOS BIOATIVOS Síntese, elucidaçã Page 1 i …
PRODUTOS NATURAIS E SINTÉTICOS BIOATIVOS Síntese, elucidaçã Page 1 i …
[PDF][PDF] Synthesis of novel heterocyclic fused pyrimidin-4-one derivatives from imino-1, 2, 3-dithiazoles
M de Fatima Pereira, E Sarghe, H Rouillard, L Domon… - Arkivoc, 2017 - arkat-usa.org
Extending the potential applications of 4, 5-dichloro-1, 2, 3-dithiazolium chloride chemistry,
we investigated the synthesis of original derivatives of thieno [2, 3-d] pyrimidin-4-one system …
we investigated the synthesis of original derivatives of thieno [2, 3-d] pyrimidin-4-one system …
Five-Membered Ring Systems: Thiophenes and Se/Te Derivatives
ER Biehl - Progress in Heterocyclic Chemistry, 2014 - Elsevier
The synthesis and chemistry of thiophenes, selenophenes, and tellurophenes are
discussed. Particular emphasis has been placed on their major contributions to medicinal …
discussed. Particular emphasis has been placed on their major contributions to medicinal …