The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

I. Introduction IN 1953 lohn Morris, an obstetrician at Yale University, reported a series of 82
individuals (80 cases collated from the literature and two cases of his own) who had a …

Overexpression of amplified genes is often associated with the acquisition of resistance to
cancer therapeutic agents in vitro. We have identified a similar molecular mechanism in vivo …

Aberrant activation of the androgen receptor (AR) may be one of the mechanisms which
contribute to progression of prostatic carcinoma to an androgen-independent stage. We …

In the mouse, Sry is expressed by germ cells in the adult testis and by somatic cells in the
genital ridge. Transcripts in the former exist as circular RNA molecules of 1.23 kb, which are …

The X-linked androgen receptor (AR) gene contains two polymorphic trinucleotide repeat
segments that code for polyglutamine and polyglycine tracts in the N-terminal trans …

Despite earlier detection and recent advances in surgery and radiation, prostate cancer is
second only to lung cancer in male cancer deaths in the United States. Hormone therapy in …

Purpose: The mechanisms responsible for prostate cancer androgen independence are
diverse. Mutations of the androgen receptor (AR) gene that broaden ligand specificity have …

We analyzed the frequency and relevance of mutations in the coding region of the androgen
receptor (AR) in genomic DNA extracted from 137 specimens of prostate cancer. The …

An androgen receptor (AR) gene mutation identified in the androgen-dependent human
prostate cancer xenograft, CWR22, changed codon 874 in the ligand-binding domain (exon …