TGF-β Signaling
K Tzavlaki, A Moustakas - Biomolecules, 2020 - mdpi.com
Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …
Specificity, versatility, and control of TGF-β family signaling
R Derynck, EH Budi - Science signaling, 2019 - science.org
Encoded in mammalian cells by 33 genes, the transforming growth factor–β (TGF-β) family
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease
Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …
TGF-β signaling from receptors to Smads
A Hata, YG Chen - Cold Spring Harbor perspectives in …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …
SEDPHAT–a platform for global ITC analysis and global multi-method analysis of molecular interactions
Isothermal titration calorimetry experiments can provide significantly more detailed
information about molecular interactions when combined in global analysis. For example …
information about molecular interactions when combined in global analysis. For example …
[HTML][HTML] Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects
M Scheffner, S Kumar - Biochimica et Biophysica Acta (BBA)-Molecular …, 2014 - Elsevier
Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …
USP8 promotes cancer progression and extracellular vesicle‐mediated CD8+ T cell exhaustion by deubiquitinating the TGF‐β receptor TβRII
F Xie, X Zhou, H Li, P Su, S Liu, R Li, J Zou… - The EMBO …, 2022 - embopress.org
TGF‐β signaling is a key player in tumor progression and immune evasion, and is
associated with poor response to cancer immunotherapies. Here, we identified ubiquitin …
associated with poor response to cancer immunotherapies. Here, we identified ubiquitin …
An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network
The ubiquitination mediated by ubiquitin activating enzyme (E1), ubiquitin conjugating
enzyme (E2), and ubiquitin ligase (E3) cascade is crucial to protein degradation …
enzyme (E2), and ubiquitin ligase (E3) cascade is crucial to protein degradation …
Smad7 protein interacts with receptor-regulated Smads (R-Smads) to inhibit transforming growth factor-β (TGF-β)/Smad signaling
TGF-β is a pleiotropic cytokine that regulates a wide range of cellular actions and
pathophysiological processes. TGF-β signaling is spatiotemporally fine-tuned. As a key …
pathophysiological processes. TGF-β signaling is spatiotemporally fine-tuned. As a key …
Bone morphogenetic protein signaling in bone homeostasis
Bone morphogenetic proteins (BMPs) are cytokines belonging to the transforming growth
factor-β (TGF-β) superfamily. They play multiple functions during development and tissue …
factor-β (TGF-β) superfamily. They play multiple functions during development and tissue …