Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …

Since the introduction of the quasispecies and the error catastrophe concepts for molecular
evolution by Eigen and their subsequent application to viral populations, increased …

The complete positive-sense single-stranded RNA genome of Cassava brown streak virus
(CBSV; genus Ipomovirus; Potyviridae) was found to consist of 9,069 nucleotides and …

A critical issue to understanding how populations adapt to new selective pressures is the
relative contribution of the initial standing genetic diversity versus that generated de novo …

The application of quasispecies theory to viral populations has boosted our understanding
of how endogenous and exogenous features condition their adaptation. Mounting empirical …

Recombination is an important driver in the evolution of viruses and thus is key to
understanding viral epidemics and improving strategies to prevent future outbreaks …

Evolution at high mutation rates is expected to reduce population fitness deterministically by
the accumulation of deleterious mutations. A high enough rate should even cause extinction …

The frequency of change in the selective pressures is one of the main factors driving
evolution. It is generally accepted that constant environments select specialist organisms …

The continuous emergence of drug-resistant viruses is a major obstacle for the successful
treatment of viral infections, thus representing a persistent spur to the search for new …

Highlights•eGFP-tagged senecavirus A (SVA) undergoes serial plaque-to-plaque
transfers.•eGFP-containing virus progeny is screened out at passage-61 for NGS.•NGS …