Adenosine receptors (ARs) are a class of G-protein coupled receptors (GPCRs) that are
activated by the endogenous substance adenosine. ARs are classified into 4 subtype …

MicroRNAs (miRNAs) are small non-coding RNA molecules capable of silencing mRNA
targets. miRNA dysregulation has been linked to cancer development, cardiovascular and …

Photoaffinity labeling (PAL) is widely used for the identification of ligand-binding proteins
and elucidation of ligand-binding sites. PAL has also been employed for the characterization …

Psychiatric and neurological disorders (PNDs) have correlated diseases and represent a
burden on public health. Several drugs are reported to repurpose PNDs therapy. Drugs with …

Background The involvement of ATP and cAMP in sperm function has been extensively
documented, but the understanding of the role of adenosine and adenosine receptors …

A pyrazolo [4, 3-e][1, 2, 4] triazolo [1, 5-c] pyrimidin-5-amine antagonist of the A2A
adenosine receptor (AR) was functionalized as amine congeners, fluorescent conjugates …

Antagonism of the adenosine A2A receptor on T cells blocks the hypoxia‐adenosinergic
pathway to promote tumor rejection. Using an in vivo immunoassay based on the …

In an effort to provide an overview of the biophysical approaches used to study G-protein-
coupled receptors, we chose to consider the adenosine A2A receptor as a model, as it is …

2.1 Introduction: Receptor Allosterism allosteric molecules are fundamentally different from
molecules that bind to the natural receptor binding pocket for endogenous hormones and …

Enhanced/prolonged cAMP signalling has been suggested as a suppressor of cancer
proliferation. Interestingly, two key modulators that elevate cAMP, the A 2A receptor (A 2A R) …