Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and
levels of mtDNA-CN have been reproducibly associated with overall mortality and a number …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

Mitochondria are essential organelles within the cell where most ATP is produced through
oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are …

Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …

During cell division, it is critical to properly partition functional sets of organelles to each
daughter cell. The partitioning of mitochondria shares some common features with that of …

Abstract The Biomarkers of Nutrition for Development (BOND) project is designed to provide
evidence-based advice to anyone with an interest in the role of nutrition in health …

Somatic cells accumulate genomic alterations with age; however, our understanding of
mitochondrial DNA (mtDNA) mosaicism remains limited. Here we investigated the genomes …

Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure
through direct interactions of radiation with target macromolecules or via products of water …

Phylogeography is a discipline concerned with various relationships between gene
genealogies—phylogenetics—and geography. The word “phylogeography” was coined in …