Nerve guidance conduit development for primary treatment of peripheral nerve transection injuries: A commercial perspective

BJ Parker, DI Rhodes, CM O'Brien, AE Rodda… - Acta Biomaterialia, 2021 - Elsevier
Commercial nerve guidance conduits (NGCs) for repair of peripheral nerve discontinuities
are of little use in gaps larger than 30 mm, and for smaller gaps they often fail to compete …

Evaluation of the aging effect on peripheral nerve regeneration: a systematic review

KC Maita, JP Garcia, FR Avila… - Journal of Surgical …, 2023 - Elsevier
Introduction Peripheral nerve injuries have been associated with increased healthcare costs
and decreased patients' quality of life. Aging represents one factor that slows the speed of …

Contact separation triboelectric nanogenerator based neural interfacing for effective sciatic nerve restoration

M Zhou, M Huang, H Zhong, C Xing… - Advanced Functional …, 2022 - Wiley Online Library
Peripheral nerve injuries represent one of the most common causes of permanent
disabilities. Therapeutic electrical stimulation has been widely used in neural regeneration …

Electrical stimulation of human neural stem cells via conductive polymer nerve guides enhances peripheral nerve recovery

S Song, KW McConnell, D Amores, A Levinson… - Biomaterials, 2021 - Elsevier
Severe peripheral nerve injuries often result in permanent loss of function of the affected
limb. Current treatments are limited by their efficacy in supporting nerve regeneration and …

Ti3C2Tx MXene-Coated Electrospun PCL Conduits for Enhancing Neurite Regeneration and Angiogenesis

LP Nan, Z Lin, F Wang, XH Jin, JQ Fang… - … in Bioengineering and …, 2022 - frontiersin.org
An electrical signal is the key basis of normal physiological function of the nerve, and the
stimulation of the electric signal also plays a very special role in the repair process of nerve …

Incorporating blood flow in nerve injury and regeneration assessment

S Yeoh, WS Warner, SS Merchant, EW Hsu… - Frontiers in …, 2022 - frontiersin.org
Peripheral nerve injury is a significant public health challenge, with limited treatment options
and potential lifelong impact on function. More than just an intrinsic part of nerve anatomy …

Evaluation of functional recovery in rats after median nerve resection and autograft repair using computerized gait analysis

JC Heinzel, V Oberhauser, C Keibl… - Frontiers in …, 2021 - frontiersin.org
Computerized gait analysis is a common evaluation method in rat models of hind limb nerve
injuries, but its use remains unpublished in models of segmental nerve injury of the forelimb …

Occurrence of lymphangiogenesis in peripheral nerve autografts contrasts Schwann cell-induced apoptosis of lymphatic endothelial cells in vitro

C Hromada, J Hartmann, J Oesterreicher, A Stoiber… - Biomolecules, 2022 - mdpi.com
Peripheral nerve injuries pose a major clinical concern world-wide, and functional recovery
after segmental peripheral nerve injury is often unsatisfactory, even in cases of autografting …

Brief electrical stimulation accelerates axon regeneration and promotes recovery following nerve transection and repair in mice

J Sayanagi, JA Acevedo-Cintrón, D Pan, L Schellhardt… - JBJS, 2021 - journals.lww.com
Background: Clinical outcomes following nerve injury repair can be inadequate. Pulsed-
current electrical stimulation (ES) is a therapeutic method that facilitates functional recovery …

Preclinical evidence for the role of botulinum neurotoxin A (BoNT/A) in the treatment of peripheral nerve injury

M Adler, S Pellett, SK Sharma, FJ Lebeda, ZF Dembek… - microorganisms, 2022 - mdpi.com
Traumatic peripheral nerve injuries tend to be more common in younger, working age
populations and can lead to long-lasting disability. Peripheral nerves have an impressive …