[HTML][HTML] Novel blood coagulation molecules: skeletal muscle myosin and cardiac myosin
H Deguchi, S Morla, JH Griffin - Journal of Thrombosis and Haemostasis, 2021 - Elsevier
Essentials• Striated muscle myosins can promote prothrombin activation by FXa or FVa
inactivation by APC.• Cardiac myosin and skeletal muscle myosin are pro‐hemostatic in …
inactivation by APC.• Cardiac myosin and skeletal muscle myosin are pro‐hemostatic in …
Skeletal muscle myosin promotes coagulation by binding factor XI via its A3 domain and enhancing thrombin-induced factor XI activation
S Morla, H Deguchi, J Zilberman-Rudenko… - Journal of Biological …, 2022 - ASBMB
Skeletal muscle myosin (SkM) has been shown to possess procoagulant activity; however,
the mechanisms of this coagulation-enhancing activity involving plasma coagulation …
the mechanisms of this coagulation-enhancing activity involving plasma coagulation …
Procoagulant activities of skeletal and cardiac muscle myosin depend on contaminating phospholipid
VA Novakovic, GE Gilbert - Blood, The Journal of the American …, 2020 - ashpublications.org
Recent reports indicate that suspended skeletal and cardiac myosin, such as might be
released during injury, can act as procoagulants by providing membrane-like support for …
released during injury, can act as procoagulants by providing membrane-like support for …
Cardiac myosin promotes thrombin generation and coagulation in vitro and in vivo
J Zilberman-Rudenko, H Deguchi… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Cardiac myosin (CM) is structurally similar to skeletal muscle myosin, which has
procoagulant activity. Here, we evaluated CM's ex vivo, in vivo, and in vitro activities related …
procoagulant activity. Here, we evaluated CM's ex vivo, in vivo, and in vitro activities related …
[HTML][HTML] Full‐length plasma skeletal muscle myosin isoform deficiency is associated with coagulopathy in acutely injured patients
JR Coleman, H Deguchi, TK Deguchi, MJ Cohen… - Journal of Thrombosis …, 2022 - Elsevier
Abstract Background Skeletal muscle myosin (SkM) molecules are procoagulant both in vitro
and in vivo. The association of plasma SkM isoforms with blood coagulability and hemostatic …
and in vivo. The association of plasma SkM isoforms with blood coagulability and hemostatic …
Plasma skeletal muscle myosin phenotypes identified by immunoblotting are associated with pulmonary embolism occurrence in young adults
TK Deguchi, H Deguchi, Z Guo, DJ Elias, JH Griffin - Thrombosis research, 2020 - Elsevier
Background Purified skeletal muscle myosin (SkM) binds factor Xa and is procoagulant. The
molecular forms of SkM in human plasma have not been characterized. Method Human …
molecular forms of SkM in human plasma have not been characterized. Method Human …
Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids
S Morla, H Deguchi, JA Fernández… - Blood, The Journal …, 2021 - ashpublications.org
Skeletal muscle myosin (SkM) and cardiac myosin (CM) are able to support prothrombinase
complex (factor (F) Xa: FVa: Ca++) activity that generates thrombin and also to support …
complex (factor (F) Xa: FVa: Ca++) activity that generates thrombin and also to support …
Vrijednost biljega hrskavice serumskog hondroitin sulfata epitopa 846 i urinarnog C-terminalnog telopeptida kolagena tipa II u ocjeni težine hemofilične artropatije
N Kalebota - 2024 - dr.nsk.hr
Sažetak Provedeno je istraživanje vrijednosti biljega uCTX-II i CS846 u ocjeni težine
hemofilične artropatije (HA) te njihove povezanosti s koštanim biljezima osteokalcinom …
hemofilične artropatije (HA) te njihove povezanosti s koštanim biljezima osteokalcinom …
[HTML][HTML] Skeletal muscle myosin and cardiac myosin attenuate heparin's antithrombin‐dependent anticoagulant activity
S Morla, H Deguchi, JH Griffin - Journal of Thrombosis and Haemostasis, 2021 - Elsevier
Background Heparin enhances the ability of the plasma protease inhibitor, antithrombin, to
neutralize coagulation factor Xa and thrombin. Skeletal muscle myosin binds unfractionated …
neutralize coagulation factor Xa and thrombin. Skeletal muscle myosin binds unfractionated …
横紋筋ミオシンと血液凝固
出口敦智， 出口洋 - 日本血栓止血学会誌, 2020 - jstage.jst.go.jp
骨格筋ミオシン (skeletal muscle myosin: SkM) は骨格筋の主要構成成分であり, 6
本のポリペプチド鎖からなる複合体である (図 1A). 一方, SkM は血漿中にも存在し …
本のポリペプチド鎖からなる複合体である (図 1A). 一方, SkM は血漿中にも存在し …