[HTML][HTML] Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies
Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …
[HTML][HTML] Bone morphogenetic protein signaling in cancer; some topics in the recent 10 years
S Ehata, K Miyazono - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β)
family, are multifunctional cytokines. BMPs have a broad range of functions, and …
family, are multifunctional cytokines. BMPs have a broad range of functions, and …
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
[HTML][HTML] Histone variant and cell context determine H3K27M reprogramming of the enhancer landscape and oncogenic state
S Nagaraja, MA Quezada, SM Gillespie, M Arzt… - Molecular cell, 2019 - cell.com
Development of effective targeted cancer therapies is fundamentally limited by our
molecular understanding of disease pathogenesis. Diffuse intrinsic pontine glioma (DIPG) is …
molecular understanding of disease pathogenesis. Diffuse intrinsic pontine glioma (DIPG) is …
[HTML][HTML] Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors
G Sanchez-Duffhues, E Williams, MJ Goumans… - Bone, 2020 - Elsevier
Bone morphogenetic proteins (BMPs) are secreted cytokines that control the fate and
function of many different cell types. They exert their cellular responses via heteromeric …
function of many different cell types. They exert their cellular responses via heteromeric …
Antisense oligonucleotide therapy for H3. 3K27M diffuse midline glioma
Q Zhang, L Yang, YH Liu, JE Wilkinson… - Science translational …, 2023 - science.org
Diffuse midline gliomas (DMGs) are pediatric high-grade brain tumors in the thalamus,
midbrain, or pons; the latter subgroup are termed diffuse intrinsic pontine gliomas (DIPG) …
midbrain, or pons; the latter subgroup are termed diffuse intrinsic pontine gliomas (DIPG) …
[HTML][HTML] Mutant ACVR1 arrests glial cell differentiation to drive tumorigenesis in pediatric gliomas
Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors for which
there is currently no effective treatment. Some of these tumors combine gain-of-function …
there is currently no effective treatment. Some of these tumors combine gain-of-function …
[HTML][HTML] Pediatric diffuse midline gliomas: an unfinished puzzle
V Di Ruscio, G Del Baldo, F Fabozzi, M Vinci… - Diagnostics, 2022 - mdpi.com
Diffuse midline glioma (DMG) is a heterogeneous group of aggressive pediatric brain tumors
with a fatal prognosis. The biological hallmark in the major part of the cases is H3K27 …
with a fatal prognosis. The biological hallmark in the major part of the cases is H3K27 …
[HTML][HTML] Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery
YS Yang, JM Kim, J Xie, S Chaugule, C Lin… - Nature …, 2022 - nature.com
Heterotopic ossification is the most disabling feature of fibrodysplasia ossificans
progressiva, an ultra-rare genetic disorder for which there is currently no prevention or …
progressiva, an ultra-rare genetic disorder for which there is currently no prevention or …
A compendium of syngeneic, transplantable pediatric high-grade glioma models reveals subtype-specific therapeutic vulnerabilities
Pediatric high-grade gliomas (pHGG) are lethal, incurable brain tumors frequently driven by
clonal mutations in histone genes. They often harbor a range of additional genetic …
clonal mutations in histone genes. They often harbor a range of additional genetic …