Successful solid organ transplantation reflects meticulous attention to the details of
immunosuppression, balancing risks for graft rejection against risks for infection. The “net …

Suppression of allograft rejection is central to successful organ transplantation; thus,
immunosuppressive agents are crucial for successful allograft function. Immunosuppressive …

Understanding rates and determinants of clinical pathologic progression for recipients with
de novo donor-specific antibody (dnDSA), especially subclinical dnDSA, may identify …

Advances in multimodal immunotherapy have significantly reduced acute rejection rates and
substantially improved 1-year graft survival following renal transplantation. However, long …

Effective immunosuppression is an essential pre-requisite for successful organ
transplantation and improvements in outcome after transplantation have to a large extent …

Background Steroid‐sparing strategies have been attempted in recent decades to avoid
morbidity from long‐term steroid intake among kidney transplant recipients. Previous …

Recent studies show that alloantibodies mediate a substantial proportion of graft-rejection
episodes, contributing to both early and late graft loss. Rejection that is caused by antibody …

A half-century has elapsed since the first transplantation, and this procedure is now
accepted as the treatment of choice for end-stage organ failure. This article reviews the …

The association between lymphopenia and autoimmunity is recognized, but the underlying
mechanisms are poorly understood and have not been studied systematically in humans …

T-cell depletion facilitates reduced immunosuppression following organ transplantation and
has been suggested to be pro-tolerant. However, the characteristics of post-depletional T …