Animal models are commonly used in the preclinical development of new drugs to predict
the metabolic behaviour of new compounds in humans. It is, however, important to realise …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Background Prediction of the exposure of neonates, infants and children to xenobiotics is
likely to be more successful using physiologically based pharmacokinetic models than …

Consistent with its highest abundance in humans, cytochrome P450 (CYP) 3A is responsible
for the metabolism of about 60% of currently known drugs. However, this unusual low …

Cytochrome P450s (CYPs) are an important family of enzymes in the metabolism of many
therapeutic agents and endogenous metabolic reactions. The CYP3A subfamily is …

Drug metabolism studies are essential and necessary during the evaluation of drugs. This
review discusses the in vitro human liver models to estimate the drug metabolic fates in vivo …

Primary hepatocytes represent a well-accepted in vitro cell culture system for studies of drug
metabolism, enzyme induction, transplantation, viral hepatitis, and hepatocyte regeneration …

Transformation of escitalopram (S-CT), the pharmacologically active S-enantiometer of
citalopram, to S-desmethyl-CT (S-DCT), and of S-DCT to S-didesmethyl-CT (S-DDCT), was …

Background Components of grapefruit juice may impair the activity of intestinal cytochrome
P450 (CYP) 3A enzymes, sometimes resulting in clinically important drug interactions. The …