Abstract Circadian (∼ 24-hour) timing systems pervade all kingdoms of life and temporally
optimize behavior and physiology in humans. Relatively recent changes to our …

The past decade has witnessed an exponential increase in the number of publications
referring to extracellular vesicles (EVs). For many years considered to be extracellular …

In evolutionary terms, GH and intracellular STAT 5 signaling is a very old regulatory system.
Whereas insulin dominates periprandially, GH may be viewed as the primary anabolic …

Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting
pituitary adenoma and leads to acromegaly—a disorder of disproportionate skeletal, tissue …

Pituitary tumors account for about 15% of primary intracranial neoplasms. Proliferation of
pituitary cells, which secrete hormones, may result in a spectrum of endocrine symptoms …

Ghrelin, an endogenous ligand for the GH secretagogue receptor, was isolated from rat
stomach and is involved in a novel system for regulating GH release. Although previous …

INSULIN-LIKE growth factor-I (IGF-I) and IGF-II growth factors that are structurally related to
insulin (Table 1). The human IGFs (refered to generically as somatomedins) are single chain …

Ghrelin, a novel GH-releasing peptide isolated from human and rat stomach, stimulates food
intake and GH secretion. We determined plasma ghrelin concentrations in patients with …

A. 24-h variations in glucose tolerance B. Causal mechanisms III. Alterations of 24-h
Rhythms of Glucose Regulation in Normal Aging A. Daytime variations in glucose tolerance …

Increased life expectancy combined with the aging baby boomer generation has resulted in
an unprecedented global expansion of the elderly population. The growing population of …